Pre-Clinical Laboratory Services
Cellomatics Biosciences Ltd. is a laboratory-based Contract Research Organisation (CRO) specialised in Oncology/Immuno-Oncology, Immunology/Inflammation and Respiratory therapeutic areas.
We provide bespoke pre-clinical/early discovery phase laboratory services to support Biotech, Pharmaceutical companies and Academic groups in their drug discovery projects. Our aim is to assist our clients in expediting their drug development programmes by providing high quality ethical services.
Cellomatics BioSciences is continually striving to offer added value to all our client discovery projects. We achieve this by constantly reviewing and evaluating new technologies that complement and augment our preclinical in vitro capabilities.
TARGET VALIDATION We offer a range of strategies for modulating gene expression in vitro including the use of antibodies, negative dominant controls, antisense oligonucleotides,ribozymes and small-interfering RNAs.
IN VITRO CELL-BASED ASSAYS Cellomatics BioSciences also have expertise in designing, developing, performing and analysing functional cell-based assays using well-established cell lines and primary cells. We offer a comprehensive panel of cell-based functional assays using a vast selection of 2D and 3D cellular, co-culture models to determine the functional efficacy of your drug candidates.
BIOMARKER VALIDATION AND QUALIFICATION Molecular biomarkers are mainly used in early drug development, safety and proof of concept studies, as well as molecular profiling. Cellomatics BioSciences provides assay development and validation for prognostic/predictive clinical and pathway activation biomarkers:
PREDICTIVE TOXICITY The main objective of pre-clinical testing is to determine the potential adverse effects, toxicity and drug/drug interactions before the drug is tested in either animal models or in a Phase 1 clinical trial. Hepato and renal in vitro toxicity tests are therefore vital for pre-screening drug compounds to reduce costs for in vivo testing and clinical trials. As the animal model might not mirror the human model completely, there is a powerful need to identify physiologically-relevant hepatic and kidney cellular models. Cellomatics BioSciences offers a vast selection of:
CONSULTANCY In consultation with you, we can design strategies for the identification and validation of targets and biomarkers to support your drug discovery programs. Our team of experienced scientists can provide consultancy to assist you in designing, developing, optimizing and validating your assays for your target and biomarker qualification work. We will provide regular electronic updates on the progress of your projects.
Our experienced team of in vitro laboratory scientists will work with you to understand your project and provide a bespoke project plan with a professional, flexible service and a fast turnaround time.
At Cellomatics BioSciences, we believe in efficient Project Management to ensure delivery of a high-quality work and complete client satisfaction.
Every project is assigned a Project Manager and a Project Director: a two-step Quality control approach. The Project Manager is the central contact point throughout the project life cycle with day to day operational responsibilities and management of the project team to produce high quality deliverables. The Project Director has an overall responsibility for the timely execution and delivery of the project within the agreed budget.