Multiplex Nucleic Acid Testing

Multiplex nucleic acid testing allows multiplexed gene expression analysis (RNA targets) and DNA copy number variation analysis, allowing researchers to measure up to 80 genes in a single well. These assays are hybridization-based using the xMAP® Luminex®magnetic beads and performed on 96-well plates. Luminex xMAP® technology combines advanced fluidics, optics, and digital signal processing with fluorescently dyed microspheres to enable the quantitation of multiple nucleic acid from a single sample. There are >17,000 targets for RNA and >700 targets for DNA available for customisation.

We have a number of assays that are applicable to clinical diagnostics, infectious diseases and genetic (pharmacogenetic testing). Luminex xTAG Technology products provide accurate, flexible, low-cost bead arrays. They combine any set of up to 150 nucleic acid tests and multiplex them in a single reaction. xTAG assays are run on the Luminex xMAP® systems, which use lasers or LEDs to read color coded microspheres that attach to specific nucleic acid sequences.

Principle of xTAG technology:

xTAG® Technology uses a proprietary universal tag system that allows easy development and optimization of nucleic acid assays.

xTAG technology

The advantages of using xTAG Technology in your nucleic acid assay are:

  • Sequences have been optimized to minimize cross-hybridization, thus preventing cross-talk in multiplexed nucleic acid assays.
  • Only three bases are used (TAG), preventing hybridization with native sequences.
  • Isothermal hybridization prevents long experimental design and testing times seen when you have to choose your own sequence.

MultiPlex Gene Assay:

Unique Benefits:

  • This Assay provides DIRECT from lysate measurement of 3 to 80 target RNAs per well with unparalleled accuracy and precision.
  • Quantitatively measure multiple RNA targets simultaneously with unparalleled accuracy and precision
  • Quantitation of original RNA population directly from lysates avoids biases, sample loss, false positive/negative results associated with
    • RNA isolation
    • cDNA synthesis
    • PCR amplification
  • High accuracy and precision using branch DNA (bDNA) signal amplification versus target amplification (PCR)
    • High precision - coefficient of variation (CV) of less than 15% for entire process (sample isolation to results)
    • High accuracy - distinguish percentage differences in RNA copy number - linear assay with low CVs
  • No optimization required for multiplexing 3 to 80 target RNAs
  • Excellent results in difficult clinical research samples, including, H&E-stained FFPE, blood, and skin

Accurate results in a variety of samples

  • Compatible with human, animal and plant tissues, FFPE tissue sections, whole blood, Tempus blood, PAXgene blood, cultured cells, isolated RNA and more

Validated panels

  • Each panel is functionally validated

Applications

  • Validation and testing of disease biomarkers (e.g. cancer, neurology, autoimmune disease, etc.)
  • Validation of microarray or sequencing results
  • Predictive toxicology
  • Secondary screening
  • Pathway analysis

MultiPlex Gene Assay Specifications

Limit of Detection ≤ 1,000-2,000 transcripts/assay well
Limit of Quantitation ≤ 2,000-4,000 transcripts/assay well
Linear Dynamic Range ≥ 3.0 logs
Assay CV ≤ 15% intra-assay;≤ 20% inter-assay
Compatible Sample Types Cultured cells, bacteria, whole blood, PAXgene blood or dried blood spots, fresh/frozen tissues (animal or plant), FFPE samples, purified RNA
Assay Format 96-well plate
Targets/well 3 - 80

Work Flow:

The assay combines branched DNA (bDNA) signal amplification and multi-analyte profiling beads (xMAP®) technologies to enable the detection and quantitation of multiple RNA targets simultaneously. The bDNA assay is a hybridization-based method of target-specific RNA quantitation that amplifies signal rather than target RNA, using labeled DNA probes. Fluorescent microspheres (Capture Beads) are used as a support to capture specific RNA molecules. The system combines a flow cytometer, fluorescent-dyed microspheres (beads), lasers and digital signal processing.

Why choos Mulitplex Gene Assays over qPCR? –

Don’t let qPCR hold you back. Multiplex Gene Assays deliver gene expression data faster.

Is qPCR still the gold standard for measuring expression?

qPCR is widely considered to be the gold standard for measuring RNA expression, but with it come several limitations. Researchers in both industrial and academic laboratories are constantly shifting their assay methods and mindset away from qPCR in favour of higher-content assays that enable them to complete their projects faster.


Are you...
  • spending too much time purifying RNA?
  • frustrated with the amount of primer design and optimization required?
  • wishing you had lower CVs, better fold-change sensitivity, or more robust Z-factors?
  • experiencing variations in priming efficiency or reverse transcription?
Imagine what you could accomplish if…
  • RNA purification was NOT necessary, saving you time.
  • reverse transcription was NOT needed, eliminating bias.
  • you could run your custom panel within two weeks of identifying your genes of interest.
  • you could analyze up to 80 targets at once, drastically reducing the number of samples to run

QuantiGene Plex Assay: Gene expression analysis without the limitations of qPCR:

QuantiGene® Plex assays provide the fastest and highest throughput solution for quantitative, multiplexed gene expression analysis.
RNA targets are directly quantified with no need for cDNA synthesis or PCR amplification.

Skip RNA purification. QuantiGene Plex assays quantitate directly from cell lysates or tissue homogenates, saving you time and minimizing issues caused by contamination or excessive RNA handling.

Reduce 20 qPCR plates to just one MultiPlex plate. With true multiplexing capability, this assay measures up to 80 genes of interest in a single well with no cross-reactivity. This capability dramatically increases your efficiency and reduces your workload, while allowing you to normalize against several reference genes all in the same reaction.

Advantages of Multiplex Gene Assays over qPCR: Save Time, Money and Sample

  • Highly efficient workflow allows measurement of as many as 80 genes of interest in a single well with no cross-reactivity.
  • Faster sample preparation as results are quantitated directly from cell lysates, eliminating the RNA purification step and minimising issues caused by contamination. Protein and gene expression data can be generated from the same sample. After a cell culture is centrifuged, the supernatant is used for multiplex immunoassay and the cell pellet can be used for multiplex nucleic acid testing. Works well with various starting material such as whole blood, tissues, cells, plant, bacteria and also with heavily degraded RNA in archived FFPE samples.
  • Less bias by avoiding reverse transcription step. RNA targets are directly quantified with no need for cDNA synthesis nor PCR amplification.
  • Faster results with validated panel of targets avoiding qPCR primer design, optimization, and sample processing.
  • High confidence in screening results gained with higher Z’-factors than qPCR results.
  • Added assurance: Make better decisions with the superior performance with better accuracy and precision.
  • Right on the money: Save 40% money measuring expression than total qPCR costs.

Cancer targets (human): ALK, AMACR, AR, BCL2, BCL6, BIRC5, BRAF, BTG2, CCR2, CLEC3B, CXCL12, EGFR, ERBB2 (Her2), ERG, EZH2, GLI1, KLK3, KRT17, KRT19, KRT5, KRT7, MACC1, MAGEA2, MCM6, MKI67, MMP1, MMP2, MMP9, MYC, NKX3-1, OR51E2, PCA3, PCGEM1, PCNA, PDZK1, PTEN, SPARC, SPP1, TEMPRSS2-ERG fusion, TP53, VEGF

Cytokine, chemokines and growth factors (human): CCL2, CSF2, FGF21, FGFR3, HGF, IL10, IL13RA2, IL17, IL17F, IL17RB, IL1RL1, IL23A, IL25, IL6, IL8, PDGFBR, SERPINE1; TGFA, TNF, TNFRSF12A, VEGF


80-plex assay panels are available for the following categories:
  • Toxicity
  • JAK-STAT
  • Angiogenesis
  • Stem Cell
  • Breast Cancer
  • Cell Cycle
  • Immunology
  • p53
  • Wnt
  • Kinase

You can also customise your assay from the panel of targets available.

(Courtesy: ebioscience.com)


symbol refseq name
AASS NM_005763 aminoadipate-semialdehyde synthase
ABCA1 NM_005502 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 NM_000927 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 NM_003742 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 NM_000443 NM_018849 NM_018850 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC2 NM_000392 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 NM_001144070 NM_003786 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 NM_001105515 NM_005845 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC6 NM_001079528 NM_001171 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCG2 NM_004827 ATP-binding cassette, sub-family G (WHITE), member 2
ABCG5 NM_022436 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 NM_022437 ATP-binding cassette, sub-family G (WHITE), member 8
ATP8B1 NM_005603 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BMP1 NM_001199 NM_006129 NR_033403 NR_033404 bone morphogenetic protein 1
COL11A1 NM_001190709 NM_001854 NM_080629 NM_080630 collagen, type XI, alpha 1
COL1A1 NM_000088 collagen, type I, alpha 1
COL1A2 NM_000089 collagen, type I, alpha 2
COL2A1 NM_001844 NM_033150 collagen, type II, alpha 1
COL3A1 NM_000090 collagen, type III, alpha 1
COL5A1 NM_000093 collagen, type V, alpha 1
COL5A2 NM_000393 collagen, type V, alpha 2
COL6A3 NM_004369 NM_057164 NM_057165 NM_057166 NM_057167 collagen, type VI, alpha 3
CYP1A2 NM_000761 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP27A1 NM_000784 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP2B6 NM_000767 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP39A1 NM_016593 cytochrome P450, family 39, subfamily A, polypeptide 1
CYP3A4 NM_017460 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP7A1 NM_000780 cytochrome P450, family 7, subfamily A, polypeptide 1
CYP7B1 NM_004820 cytochrome P450, family 7, subfamily B, polypeptide 1
CYP8B1 NM_004391 cytochrome P450, family 8, subfamily B, polypeptide 1
FABP1 NM_001443 fatty acid binding protein 1, liver
GSTA1 NM_145740 glutathione S-transferase alpha 1
GSTA2 NM_000846 glutathione S-transferase alpha 2
GSTA4 NM_001512 glutathione S-transferase alpha 4
GSTM1 NM_000561 NM_146421 glutathione S-transferase mu 1
GSTM2 NM_000848 NM_001142368 glutathione S-transferase mu 2 (muscle)
GSTM3 NM_000849 NR_024537 glutathione S-transferase mu 3 (brain)
GSTM4 NM_000850 NM_147148 NR_024538 glutathione S-transferase mu 4
GSTO1 NM_001191002 NM_001191003 NM_004832 glutathione S-transferase omega 1
GSTP1 NM_000852 glutathione S-transferase pi 1
GSTT1 NM_000853 glutathione S-transferase theta 1
GSTT2 NM_000854 glutathione S-transferase theta 2
IGFBP3 NM_000598 NM_001013398 insulin-like growth factor binding protein 3
MGST1 NM_020300 NM_145764 NM_145791 NM_145792 microsomal glutathione S-transferase 1
NQO1 NM_000903 NM_001025433 NM_001025434 NAD(P)H dehydrogenase, quinone 1
PPARA NM_001001928 NM_005036 peroxisome proliferator-activated receptor alpha
SLC10A1 NM_003049 solute carrier family 10 (sodium/bile acid cotransporter family), member 1
SLC16A1 NM_001166496 NM_003051 solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
SLC22A1 NM_003057 NM_153187 solute carrier family 22 (organic cation transporter), member 1
SLC22A5 NM_003060 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC22A7 NM_006672 NM_153320 solute carrier family 22 (organic anion transporter), member 7
SLC27A5 NM_012254 solute carrier family 27 (fatty acid transporter), member 5
SLC29A1 NM_001078174 NM_001078175 NM_001078176 NM_001078177 NM_004955 solute carrier family 29 (nucleoside transporters), member 1
SLC3A1 NM_000341 solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
SLC47A1 NM_018242 solute carrier family 47, member 1
SLC6A6 NM_001134367 NM_001134368 NM_003043 solute carrier family 6 (neurotransmitter transporter, taurine), member 6
SLC7A9 NM_001126335 NM_014270 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
SLCO1A2 NM_021094 NM_134431 solute carrier organic anion transporter family, member 1A2
SLCO1B1 NM_006446 solute carrier organic anion transporter family, member 1B1
SLCO1B3 NM_019844 solute carrier organic anion transporter family, member 1B3
SLCO2B1 NM_001145211 NM_001145212 NM_007256 solute carrier organic anion transporter family, member 2B1
UGT1A1 NM_000463 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A3 NM_019093 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 NM_007120 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A6 NM_001072 NM_205862 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A9 NM_021027 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2A3 NM_024743 NR_024010 UDP glucuronosyltransferase 2 family, polypeptide A3
UGT2B10 NM_001075 NM_001144767 UDP glucuronosyltransferase 2 family, polypeptide B10
UGT2B15 NM_001076 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 NM_001077 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B28 NM_053039 UDP glucuronosyltransferase 2 family, polypeptide B28
UGT2B4 NM_021139 UDP glucuronosyltransferase 2 family, polypeptide B4
UGT2B7 NM_001074 UDP glucuronosyltransferase 2 family, polypeptide B7
UGT3A1 NM_001171873 NM_152404 UDP glycosyltransferase 3 family, polypeptide A1
UGT3A2 NM_001168316 NM_174914 NR_031764 UDP glycosyltransferase 3 family,polypeptide A2
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
symbol refseq name
A2M NM_000014 alpha-2-macroglobulin
BCL2L1 NM_001191 NM_138578 BCL2-like 1
CCND1 NM_053056 cyclin D1
CDKN1A NM_000389 NM_078467 cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB NM_005194 CCAAT/enhancer binding protein (C/EBP), beta
CISH NM_013324 NM_145071 cytokine inducible SH2-containing protein
CLCF1 NM_001166212 NM_013246 cardiotrophin-like cytokine factor 1
CNTF NM_000614 ciliary neurotrophic factor
CNTFR NM_001842 NM_147164 ciliary neurotrophic factor receptor
CREBBP NM_001079846 NM_004380 CREB binding protein
CRK NM_005206 NM_016823 v-crk sarcoma virus CT10 oncogene homolog (avian)
CRP NM_000567 C-reactive protein, pentraxin-related
CSF1R NM_005211 colony stimulating factor 1 receptor
CSF2 NM_000758 colony stimulating factor 2 (granulocyte-macrophage)
EGFR NM_005228 NM_201282 NM_201283 NM_201284 epidermal growth factor receptor
EPOR NM_000121 NR_033663 erythropoietin receptor
FAS NM_000043 NM_152871 NM_152872 NR_028033 NR_028034 NR_028035 NR_028036 Fas (TNF receptor superfamily, member 6)
GBP1 NM_002053 guanylate binding protein 1, interferon-inducible, 67kDa
GHR NM_000163 growth hormone receptor
IFNAR1 NM_000629 interferon (alpha, beta and omega) receptor 1
IFNG NM_000619 interferon, gamma
IFNGR1 NM_000416 interferon gamma receptor 1
IL10 NM_000572 interleukin 10
IL10RA NM_001558 NR_026691 interleukin 10 receptor, alpha
IL10RB NM_000628 interleukin 10 receptor, beta
IL20 NM_018724 interleukin 20
IL2RA NM_000417 interleukin 2 receptor, alpha
IL2RG NM_000206 interleukin 2 receptor, gamma
IL4 NM_000589 NM_172348 interleukin 4
IL4R NM_000418 NM_001008699 interleukin 4 receptor
IL6ST NM_001190981 NM_002184 NM_175767 interleukin 6 signal transducer (gp130, oncostatin M receptor)
INSR NM_000208 NM_001079817 insulin receptor
IRF1 NM_002198 interferon regulatory factor 1
ISG15 NM_005101 ISG15 ubiquitin-like modifier
JAK1 NM_002227 Janus kinase 1
JAK2 NM_004972 Janus kinase 2
JAK3 NM_000215 Janus kinase 3
JUN NM_002228 jun proto-oncogene
LEP NM_000230 leptin
LEPR NM_001003679 NM_001003680 NM_002303 leptin receptor
MPL NM_005373 myeloproliferative leukemia virus oncogene
MYC NM_002467 v-myc myelocytomatosis viral oncogene homolog (avian)
NFKB1 NM_001165412 NM_003998 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
OSM NM_020530 oncostatin M
PIAS1 NM_016166 protein inhibitor of activated STAT, 1
PIAS2 NM_004671 NM_173206 protein inhibitor of activated STAT, 2
PRLR NM_000949 prolactin receptor
PTPN1 NM_002827 protein tyrosine phosphatase, non-receptor type 1
PTPN6 NM_002831 NM_080548 NM_080549 protein tyrosine phosphatase, non-receptor type 6
PTPRC NM_002838 NM_080921 NM_080923 protein tyrosine phosphatase, receptor type, C
SH2B1 NM_001145795 NM_001145796 NM_001145797 NM_001145812 NM_015503 SH2B adaptor protein 1
SIT1 NM_014450 signaling threshold regulating transmembrane adaptor 1
SLA2 NM_032214 NM_175077 Src-like-adaptor 2
SMAD1 NM_001003688 NM_005900 SMAD family member 1
SMAD2 NM_001003652 NM_001135937 NM_005901 SMAD family member 2
SMAD3 NM_001145102 NM_001145103 NM_001145104 NM_005902 SMAD family member 3
SOCS1 NM_003745 suppressor of cytokine signaling 1
SOCS2 NM_003877 suppressor of cytokine signaling 2
SOCS3 NM_003955 suppressor of cytokine signaling 3
SOCS4 NM_080867 NM_199421 suppressor of cytokine signaling 4
SOCS5 NM_014011 NM_144949 suppressor of cytokine signaling 5
SP1 NM_003109 NM_138473 Sp1 transcription factor
STAM NM_003473 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAM2 NM_005843 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAT1 NM_007315 NM_139266 signal transducer and activator of transcription 1, 91kDa
STAT2 NM_005419 NM_198332 signal transducer and activator of transcription 2, 113kDa
STAT3 NM_003150 NM_139276 NM_213662 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 NM_003151 signal transducer and activator of transcription 4
STAT5A NM_003152 signal transducer and activator of transcription 5A
STAT5B NM_012448 signal transducer and activator of transcription 5B
STAT6 NM_001178078 NM_001178079 NM_001178080 NM_001178081 NM_003153 NR_033659 signal transducer and activator of transcription 6, interleukin-4 induced
STUB1 NM_005861 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
THPO NM_000460 NM_001177597 NM_001177598 thrombopoietin
TSLP NM_033035 NR_033425 thymic stromal lymphopoietin
TYK2 NM_003331 tyrosine kinase 2
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
symbol refseq name
AGT NM_000029 angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 NM_001014431 NM_001014432 NM_005163 v-akt murine thymoma viral oncogene homolog 1
ANGPT1 NM_001146 angiopoietin 1
ANGPT2 NM_001118887 NM_001118888 NM_001147 angiopoietin 2
ANPEP NM_001150 alanyl (membrane) aminopeptidase
BAI1 NM_001702 brain-specific angiogenesis inhibitor 1
BCL2L1 NM_001191 NM_138578 BCL2-like 1
CCL2 NM_002982 chemokine (C-C motif) ligand 2
CCND1 NM_053056 cyclin D1
CDH5 NM_001795 cadherin 5, type 2 (vascular endothelium)
COL18A1 NM_030582 NM_130444 NM_130445 collagen, type XVIII, alpha 1
CXCL1 NM_001511 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 NM_002090 chemokine (C-X-C motif) ligand 3
EFNA1 NM_004428 NM_182685 ephrin-A1
EGF NM_001178130 NM_001178131 NM_001963 epidermal growth factor
ELK1 NM_001114123 NM_005229 ELK1, member of ETS oncogene family
ENG NM_000118 NM_001114753 endoglin
EPHB4 NM_004444 EPH receptor B4
EREG NM_001432 epiregulin
FGF1 NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_033136 NM_033137 NR_026695 NR_026696 fibroblast growth factor 1 (acidic)
FGFR3 NM_000142 NM_001163213 NM_022965 fibroblast growth factor receptor 3
FIGF NM_004469 c-fos induced growth factor (vascular endothelial growth factor D)
FLT1 NM_001159920 NM_001160030 NM_001160031 NM_002019 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
GRB2 NM_002086 NM_203506 growth factor receptor-bound protein 2
HAND2 NM_021973 heart and neural crest derivatives expressed 2
HGF NM_000601 NM_001010931 NM_001010932 NM_001010933 NM_001010934 hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A NM_001530 NM_181054 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HPSE NM_001098540 NM_001166498 NM_006665 heparanase
ID1 NM_002165 NM_181353 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 NM_002167 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFNA1 NM_024013 interferon, alpha 1
IFNB1 NM_002176 interferon, beta 1, fibroblast
IFNG NM_000619 interferon, gamma
IL6 NM_000600 interleukin 6 (interferon, beta 2)
IL8 NM_000584 interleukin 8
ITGAV NM_001144999 NM_001145000 NM_002210 integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
ITGB3 NM_000212 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAG1 NM_000214 jagged 1
KDR NM_002253 kinase insert domain receptor (a type III receptor tyrosine kinase)
LAMA5 NM_005560 laminin, alpha 5
LECT1 NM_001011705 NM_007015 leukocyte cell derived chemotaxin 1
LEP NM_000230 leptin
MAP2K1 NM_002755 mitogen-activated protein kinase kinase 1
MDK NM_001012333 NM_001012334 NM_002391 midkine (neurite growth-promoting factor 2)
MMP2 NM_001127891 NM_004530 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
MPL NM_005373 myeloproliferative leukemia virus oncogene
MYC NM_002467 v-myc myelocytomatosis viral oncogene homolog (avian)
NOTCH4 NM_004557 notch 4
NRP1 NM_001024628 NM_001024629 NM_003873 neuropilin 1
OSM NM_020530 oncostatin M
OSMR NM_001168355 NM_003999 oncostatin M receptor
PDGFA NM_002607 NM_033023 platelet-derived growth factor alpha polypeptide
PECAM1 NM_000442 XR_109420 platelet/endothelial cell adhesion molecule
PF4 NM_002619 platelet factor 4
PGF NM_002632 placental growth factor
PLAU NM_001145031 NM_002658 plasminogen activator, urokinase
PLG NM_000301 NM_001168338 plasminogen
PLXDC1 NM_020405 plexin domain containing 1
PROK2 NM_001126128 NM_021935 prokineticin 2
PTGS1 NM_000962 NM_080591 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 NM_000963 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
S1PR1 NM_001400 sphingosine-1-phosphate receptor 1
SERPINF1 NM_002615 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOS1 NM_005633 son of sevenless homolog 1 (Drosophila)
SPHK1 NM_001142601 NM_001142602 NM_021972 NM_182965 sphingosine kinase 1
STAB1 NM_015136 stabilin 1
STAT1 NM_007315 NM_139266 signal transducer and activator of transcription 1, 91kDa
TEK NM_000459 TEK tyrosine kinase, endothelial
TGFB1 NM_000660 transforming growth factor, beta 1
TGFB2 NM_001135599 NM_003238 transforming growth factor, beta 2
TGFBR1 NM_001130916 NM_004612 transforming growth factor, beta receptor 1
THBS1 NM_003246 thrombospondin 1
TIMP1 NM_003254 TIMP metallopeptidase inhibitor 1
TNF NM_000594 tumor necrosis factor
VEGFA NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_001171622 NM_001171623 NM_001171624 NM_001171625 NM_001171626 NM_001171627 NM_001171628 NM_001171629 NM_001171630 NM_003376 vascular endothelial growth factor A
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
symbol refseq name
ABCG2 NM_004827 ATP-binding cassette, sub-family G (WHITE), member 2
ACTC1 NM_005159 actin, alpha, cardiac muscle 1
ADAR NM_001025107 NM_001111 NM_001193495 NM_015840 NM_015841 adenosine deaminase, RNA-specific
ALDH1A1 NM_000689 aldehyde dehydrogenase 1 family, member A1
ALDH2 NM_000690 aldehyde dehydrogenase 2 family (mitochondrial)
APC NM_000038 NM_001127510 NM_001127511 adenomatous polyposis coli
ASCL2 NM_005170 achaete-scute complex homolog 2 (Drosophila)
AXIN1 NM_003502 NM_181050 axin 1
BMP1 NM_001199 NM_006129 NR_033403 NR_033404 bone morphogenetic protein 1
BMP2 NM_001200 bone morphogenetic protein 2
BTRC NM_003939 NM_033637 beta-transducin repeat containing
CCND1 NM_053056 cyclin D1
CCNE1 NM_001238 NM_057182 cyclin E1
CD4 NM_000616 NM_001195014 NM_001195015 NM_001195016 NM_001195017 NR_036545 CD4 molecule
CD44 NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 CD44 molecule (Indian blood group)
CD8A NM_001145873 NM_001768 NM_171827 NR_027353 CD8a molecule
CDH1 NM_004360 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 NM_001792 cadherin 2, type 1, N-cadherin (neuronal)
COL1A1 NM_000088 collagen, type I, alpha 1
CREBBP NM_001079846 NM_004380 CREB binding protein
CTNNA1 NM_001903 catenin (cadherin-associated protein), alpha 1, 102kDa
CXCL12 NM_000609 NM_001033886 NM_001178134 NM_199168 chemokine (C-X-C motif) ligand 12
DHH NM_021044 desert hedgehog
DLL1 NM_005618 delta-like 1 (Drosophila)
DTX1 NM_004416 deltex homolog 1 (Drosophila)
DVL1 NM_004421 dishevelled, dsh homolog 1 (Drosophila)
DVL3 NM_004423 dishevelled, dsh homolog 3 (Drosophila)
EP300 NM_001429 E1A binding protein p300
FGF1 NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_033136 NM_033137 NR_026695 NR_026696 fibroblast growth factor 1 (acidic)
FGFR1 NM_001174063 NM_001174064 NM_001174065 NM_001174066 NM_001174067 NM_015850 NM_023105 NM_023106 NM_023110 fibroblast growth factor receptor 1
FOXA2 NM_021784 NM_153675 forkhead box A2
FOXD3 NM_012183 forkhead box D3
FRAT1 NM_005479 frequently rearranged in advanced T-cell lymphomas
FZD1 NM_003505 frizzled homolog 1 (Drosophila)
FZD3 NM_017412 frizzled homolog 3 (Drosophila)
FZD8 NM_031866 frizzled homolog 8 (Drosophila)
GDF3 NM_020634 growth differentiation factor 3
GJB1 NM_000166 NM_001097642 gap junction protein, beta 1, 32kDa
GLI1 NM_001160045 NM_001167609 NM_005269 GLI family zinc finger 1
HDAC1 NM_004964 histone deacetylase 1
HDAC2 NM_001527 NR_033441 histone deacetylase 2
HES1 NM_005524 hairy and enhancer of split 1, (Drosophila)
IGF1 NM_000618 NM_001111283 NM_001111284 NM_001111285 insulin-like growth factor 1 (somatomedin C)
ISL1 NM_002202 ISL LIM homeobox 1
JAG1 NM_000214 jagged 1
JUN NM_002228 jun proto-oncogene
KRT15 NM_002275 keratin 15
MME NM_000902 NM_007287 NM_007288 NM_007289 membrane metallo-endopeptidase
MYC NM_002467 v-myc myelocytomatosis viral oncogene homolog (avian)
MYOD1 NM_002478 myogenic differentiation 1
NANOG NM_024865 Nanog homeobox
NCAM1 NM_000615 NM_001076682 NM_181351 neural cell adhesion molecule 1
NCSTN NM_015331 nicastrin
NOTCH1 NM_017617 notch 1
NOTCH2 NM_024408 notch 2
NOTCH4 NM_004557 notch 4
NUMB NM_001005743 NM_001005744 NM_001005745 NM_003744 numb homolog (Drosophila)
PAFAH1B1 NM_000430 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDX1 NM_000209 pancreatic and duodenal homeobox 1
PPARD NM_001171818 NM_001171819 NM_001171820 NM_006238 NM_177435 peroxisome proliferator-activated receptor delta
PSEN1 NM_000021 NM_007318 presenilin 1
PSENEN NM_172341 presenilin enhancer 2 homolog (C. elegans)
RAC1 NM_006908 NM_018890 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RB1 NM_000321 retinoblastoma 1
RHOA NM_001664 ras homolog gene family, member A
S100B NM_006272 S100 calcium binding protein B
SHH NM_000193 sonic hedgehog
SMAD4 NM_005359 SMAD family member 4
SMO NM_005631 smoothened homolog (Drosophila)
SOX1 NM_005986 SRY (sex determining region Y)-box 1
SUFU NM_001178133 NM_016169 suppressor of fused homolog (Drosophila)
T NM_003181 T, brachyury homolog (mouse)
TCF7 NM_001134851 NM_003202 NM_201632 NM_201634 NM_213648 NR_033449 transcription factor 7 (T-cell specific, HMG-box)
TERT NM_001193376 NM_198253 telomerase reverse transcriptase
WNT1 NM_005430 wingless-type MMTV integration site family, member 1
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
symbol refseq name
AR NM_000044 NM_001011645 androgen receptor
BAD NM_004322 NM_032989 BCL2-associated agonist of cell death
BAG1 NM_001172415 NM_004323 BCL2-associated athanogene
BCL2 NM_000633 NM_000657 B-cell CLL/lymphoma 2
BCL2L2 NM_004050 BCL2-like 2
C3 NM_000064 complement component 3
CCNA1 NM_001111045 NM_001111046 NM_001111047 NM_003914 cyclin A1
CCNA2 NM_001237 cyclin A2
CCND1 NM_053056 cyclin D1
CCNE1 NM_001238 NM_057182 cyclin E1
CD44 NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 CD44 molecule (Indian blood group)
CDH1 NM_004360 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A NM_000389 NM_078467 cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A NM_000077 NM_058195 NM_058197 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
CLDN7 NM_001185022 NM_001185023 NM_001307 claudin 7
CLU NM_001171138 NM_001831 NM_203339 clusterin
COL6A1 NM_001848 collagen, type VI, alpha 1
CTNNB1 NM_001098209 NM_001098210 NM_001904 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB NM_001908 NM_147780 NM_147781 NM_147782 NM_147783 cathepsin B
CTSD NM_001909 cathepsin D
CYP19A1 NM_000103 NM_031226 cytochrome P450, family 19, subfamily A, polypeptide 1
DLC1 NM_001164271 NM_006094 NM_024767 NM_182643 deleted in liver cancer 1
EGFR NM_005228 NM_201282 NM_201283 NM_201284 epidermal growth factor receptor
ERBB2 NM_001005862 NM_004448 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
ESR1 NM_000125 NM_001122740 NM_001122741 NM_001122742 estrogen receptor 1
ESR2 NM_001040275 NM_001040276 NM_001437 estrogen receptor 2 (ER beta)
FAS NM_000043 NM_152871 NM_152872 NR_028033 NR_028034 NR_028035 NR_028036 Fas (TNF receptor superfamily, member 6)
FASLG NM_000639 Fas ligand (TNF superfamily, member 6)
FGF1 NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_033136 NM_033137 NR_026695 NR_026696 fibroblast growth factor 1 (acidic)
FLRT1 NM_013280 fibronectin leucine rich transmembrane protein 1
FOSL1 NM_005438 FOS-like antigen 1
GABRP NM_014211 gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 NM_001002295 NM_002051 GATA binding protein 3
GNAS NM_000516 NM_001077488 NM_001077489 NM_001077490 NM_016592 NM_080425 NM_080426 NR_003259 GNAS complex locus
GSN NM_000177 NM_001127662 NM_001127663 NM_001127664 NM_001127665 NM_001127666 NM_001127667 NM_198252 gelsolin
HMGB1 NM_002128 high-mobility group box 1
HSPB1 NM_001540 heat shock 27kDa protein 1
ID2 NM_002166 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 NM_000597 insulin-like growth factor binding protein 2, 36kDa
IL2RA NM_000417 interleukin 2 receptor, alpha
IL6 NM_000600 interleukin 6 (interferon, beta 2)
IL6R NM_000565 NM_181359 interleukin 6 receptor
ITGA6 NM_000210 NM_001079818 integrin, alpha 6
ITGB4 NM_000213 NM_001005619 NM_001005731 integrin, beta 4
JUN NM_002228 jun proto-oncogene
KIT NM_000222 NM_001093772 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF5 NM_001730 Kruppel-like factor 5 (intestinal)
KLK5 NM_001077491 NM_001077492 NM_012427 kallikrein-related peptidase 5
KRT18 NM_000224 NM_199187 keratin 18
MAP2K7 NM_145185 mitogen-activated protein kinase kinase 7
MKI67 NM_001145966 NM_002417 antigen identified by monoclonal antibody Ki-67
MT3 NM_005954 metallothionein 3
MUC1 NM_001018016 NM_001018017 NM_001044390 NM_001044391 NM_001044392 NM_001044393 NM_002456 mucin 1, cell surface associated
NFYB NM_006166 nuclear transcription factor Y, beta
NGFR NM_002507 nerve growth factor receptor
NME1 NM_000269 NM_198175 non-metastatic cells 1, protein (NM23A) expressed in
PAPPA NM_002581 pregnancy-associated plasma protein A, pappalysin 1
PGR NM_000926 progesterone receptor
PLAU NM_001145031 NM_002658 plasminogen activator, urokinase
PTEN NM_000314 phosphatase and tensin homolog
PTGS2 NM_000963 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAC2 NM_002872 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
SCGB1D2 NM_006551 secretoglobin, family 1D, member 2
SERPINA3 NM_001085 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 NM_000602 NM_001165413 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A5 NM_003486 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
SPRR1B NM_003125 small proline-rich protein 1B
STC2 NM_003714 stanniocalcin 2
TFF1 NM_003225 trefoil factor 1
TGFA NM_001099691 NM_003236 transforming growth factor, alpha
THBS1 NM_003246 thrombospondin 1
TNFAIP2 NM_006291 tumor necrosis factor, alpha-induced protein 2
TOP2A NM_001067 topoisomerase (DNA) II alpha 170kDa
TP53 NM_000546 NM_001126112 NM_001126113 NM_001126114 NM_001126115 NM_001126116 NM_001126117 tumor protein p53
VEGFA NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_001171622 NM_001171623 NM_001171624 NM_001171625 NM_001171626 NM_001171627 NM_001171628 NM_001171629 NM_001171630 NM_003376 vascular endothelial growth factor A
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
symbol refseq name
ABL1 NM_005157 NM_007313 c-abl oncogene 1, non-receptor tyrosine kinase
ANAPC2 NM_013366 anaphase promoting complex subunit 2
ANAPC4 NM_013367 anaphase promoting complex subunit 4
AR NM_000044 NM_001011645 androgen receptor
ATF2 NM_001880 activating transcription factor 2
ATM NM_000051 ataxia telangiectasia mutated
ATR NM_001184 ataxia telangiectasia and Rad3 related
BCCIP NM_016567 NM_078468 NM_078469 BRCA2 and CDKN1A interacting protein
BCL2 NM_000633 NM_000657 B-cell CLL/lymphoma 2
BIRC5 NM_001012270 NM_001012271 NM_001168 baculoviral IAP repeat-containing 5
BRCA1 NM_007294 NM_007297 NM_007298 NM_007299 NM_007300 NR_027676 breast cancer 1, early onset
BRCA2 NM_000059 breast cancer 2, early onset
CCNA1 NM_001111045 NM_001111046 NM_001111047 NM_003914 cyclin A1
CCNB1 NM_031966 cyclin B1
CCNB2 NM_004701 cyclin B2
CCND1 NM_053056 cyclin D1
CCND2 NM_001759 cyclin D2
CCNE1 NM_001238 NM_057182 cyclin E1
CCNG2 NM_004354 cyclin G2
CCNH NM_001239 cyclin H
CD44 NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 CD44 molecule (Indian blood group)
CDC16 NM_001078645 NM_003903 cell division cycle 16 homolog (S. cerevisiae)
CDC20 NM_001255 cell division cycle 20 homolog (S. cerevisiae)
CDC34 NM_004359 cell division cycle 34 homolog (S. cerevisiae)
CDK1 NM_001170406 NM_001170407 NM_001786 NM_033379 cyclin-dependent kinase 1
CDK2 NM_001798 NM_052827 cyclin-dependent kinase 2
CDK4 NM_000075 cyclin-dependent kinase 4
CDK6 NM_001145306 NM_001259 cyclin-dependent kinase 6
CDK7 NM_001799 cyclin-dependent kinase 7
CDKN1A NM_000389 NM_078467 cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B NM_004064 cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A NM_000077 NM_058195 NM_058197 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
CDKN2B NM_004936 NM_078487 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHEK1 NM_001114121 NM_001114122 NM_001274 CHK1 checkpoint homolog (S. pombe)
CHEK2 NM_001005735 NM_007194 NM_145862 CHK2 checkpoint homolog (S. pombe)
COL6A1 NM_001848 collagen, type VI, alpha 1
CUL1 NM_003592 cullin 1
DDX11 NM_004399 NM_030653 NM_152438 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
DIRAS3 NM_004675 DIRAS family, GTP-binding RAS-like 3
DNM2 NM_001005360 NM_001005361 NM_001005362 NM_001190716 NM_004945 dynamin 2
E2F4 NM_001950 E2F transcription factor 4, p107/p130-binding
FLRT1 NM_013280 fibronectin leucine rich transmembrane protein 1
GADD45A NM_001924 growth arrest and DNA-damage-inducible, alpha
GTSE1 NM_016426 G-2 and S-phase expressed 1
HDAC1 NM_004964 histone deacetylase 1
HMGB1 NM_002128 high-mobility group box 1
HSD11B1 NM_005525 NM_181755 hydroxysteroid (11-beta) dehydrogenase 1
HUS1 NM_004507 HUS1 checkpoint homolog (S. pombe)
KNTC1 NM_014708 kinetochore associated 1
KPNA2 NM_002266 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT18 NM_000224 NM_199187 keratin 18
MAD2L1 NM_002358 MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2 NM_001127325 NM_006341 MAD2 mitotic arrest deficient-like 2 (yeast)
MAP2K7 NM_145185 mitogen-activated protein kinase kinase 7
MCM2 NM_004526 minichromosome maintenance complex component 2
MCM3 NM_002388 minichromosome maintenance complex component 3
MCM4 NM_005914 NM_182746 minichromosome maintenance complex component 4
MCM5 NM_006739 minichromosome maintenance complex component 5
MKI67 NM_001145966 NM_002417 antigen identified by monoclonal antibody Ki-67
MNAT1 NM_001177963 NM_002431 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)
MRE11A NM_005590 NM_005591 MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN NM_002485 nibrin
PCNA NM_002592 NM_182649 proliferating cell nuclear antigen
PRMT5 NM_001039619 NM_006109 protein arginine methyltransferase 5
RAD51 NM_001164269 NM_001164270 NM_002875 NM_133487 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
RB1 NM_000321 retinoblastoma 1
RBBP8 NM_002894 NM_203291 NM_203292 retinoblastoma binding protein 8
RBL1 NM_002895 NM_183404 retinoblastoma-like 1 (p107)
RBL2 NM_005611 retinoblastoma-like 2 (p130)
RPA3 NM_002947 replication protein A3, 14kDa
SKP2 NM_005983 NM_032637 S-phase kinase-associated protein 2 (p45)
TFDP1 NM_007111 NR_026580 transcription factor Dp-1
TFDP2 NM_001178138 NM_001178139 NM_001178140 NM_001178141 NM_001178142 NM_006286 transcription factor Dp-2 (E2F dimerization partner 2)
TP53 NM_000546 NM_001126112 NM_001126113 NM_001126114 NM_001126115 NM_001126116 NM_001126117 tumor protein p53
UGT1A1 NM_000463 UDP glucuronosyltransferase 1 family, polypeptide A1
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
symbol refseq name
BCL2 NM_000633 NM_000657 B-cell CLL/lymphoma 2
C5 NM_001735 complement component 5
C8A NM_000562 complement component 8, alpha polypeptide
CAMP NM_004345 cathelicidin antimicrobial peptide
CASP1 NM_001223 NM_033292 NM_033293 NM_033294 NM_033295 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
CASP3 NM_004346 NM_032991 caspase 3, apoptosis-related cysteine peptidase
CASP8 NM_001080124 NM_001080125 NM_001228 NM_033355 NM_033356 NM_033358 caspase 8, apoptosis-related cysteine peptidase
CCL2 NM_002982 chemokine (C-C motif) ligand 2
CCL4 NM_002984 chemokine (C-C motif) ligand 4
CCL5 NM_002985 chemokine (C-C motif) ligand 5
CCL8 NM_005623 chemokine (C-C motif) ligand 8
CCR2 NM_001123041 NM_001123396 chemokine (C-C motif) receptor 2
CCR5 NM_000579 NM_001100168 chemokine (C-C motif) receptor 5
CD14 NM_000591 NM_001040021 NM_001174104 NM_001174105 CD14 molecule
CD4 NM_000616 NM_001195014 NM_001195015 NM_001195016 NM_001195017 NR_036545 CD4 molecule
CD44 NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 CD44 molecule (Indian blood group)
CDKN1A NM_000389 NM_078467 cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB NM_005194 CCAAT/enhancer binding protein (C/EBP), beta
CHUK NM_001278 conserved helix-loop-helix ubiquitous kinase
CR2 NM_001006658 NM_001877 complement component (3d/Epstein Barr virus) receptor 2
CX3CL1 NM_002996 chemokine (C-X3-C motif) ligand 1
CXCL12 NM_000609 NM_001033886 NM_001178134 NM_199168 chemokine (C-X-C motif) ligand 12
CXCR4 NM_001008540 NM_003467 chemokine (C-X-C motif) receptor 4
CYBB NM_000397 cytochrome b-245, beta polypeptide
FCAR NM_002000 NM_133269 NM_133271 NM_133272 NM_133273 NM_133274 NM_133277 NM_133278 NM_133279 Fc fragment of IgA, receptor for
FN1 NM_002026 NM_054034 NM_212474 NM_212476 NM_212478 NM_212482 fibronectin 1
IFNA1 NM_024013 interferon, alpha 1
IFNB1 NM_002176 interferon, beta 1, fibroblast
IFNG NM_000619 interferon, gamma
IFNGR1 NM_000416 interferon gamma receptor 1
IKBKB NM_001190720 NM_001190721 NM_001190722 NM_001556 NR_033818 NR_033819 NR_033820 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 NM_000572 interleukin 10
IL12B NM_002187 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
IL16 NM_001172128 NM_004513 NM_172217 interleukin 16 (lymphocyte chemoattractant factor)
IL1A NM_000575 interleukin 1, alpha
IL1B NM_000576 interleukin 1, beta
IL1R1 NM_000877 interleukin 1 receptor, type I
IL1R2 NM_004633 NM_173343 interleukin 1 receptor, type II
IL1RAP NM_001167928 NM_001167929 NM_001167930 NM_001167931 NM_002182 NM_134470 interleukin 1 receptor accessory protein
IL1RL2 NM_003854 interleukin 1 receptor-like 2
IL2 NM_000586 interleukin 2
IL6 NM_000600 interleukin 6 (interferon, beta 2)
IL8 NM_000584 interleukin 8
IRAK1 NM_001025242 NM_001025243 NM_001569 interleukin-1 receptor-associated kinase 1
IRAK2 NM_001570 interleukin-1 receptor-associated kinase 2
IRF1 NM_002198 interferon regulatory factor 1
KLRD1 NM_001114396 NM_002262 NM_007334 killer cell lectin-like receptor subfamily D, member 1
LTBR NM_002342 lymphotoxin beta receptor (TNFR superfamily, member 3)
LTF NM_002343 lactotransferrin
LY96 NM_015364 lymphocyte antigen 96
MAPK14 NM_001315 NM_139012 NM_139013 NM_139014 mitogen-activated protein kinase 14
MBL2 NM_000242 mannose-binding lectin (protein C) 2, soluble (opsonic defect)
MYD88 NM_001172566 NM_001172567 NM_001172568 NM_001172569 NM_002468 myeloid differentiation primary response gene (88)
NCF4 NM_000631 NM_013416 neutrophil cytosolic factor 4, 40kDa
NFATC1 NM_006162 NM_172387 NM_172388 NM_172389 NM_172390 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 NM_001165412 NM_003998 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA NM_020529 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PPBP NM_002704 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTAFR NM_000952 NM_001164721 NM_001164722 NM_001164723 platelet-activating factor receptor
SELL NM_000655 NR_029467 selectin L
STAT1 NM_007315 NM_139266 signal transducer and activator of transcription 1, 91kDa
STAT3 NM_003150 NM_139276 NM_213662 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFB1 NM_000660 transforming growth factor, beta 1
TLR1 NM_003263 toll-like receptor 1
TLR2 NM_003264 toll-like receptor 2
TLR3 NM_003265 toll-like receptor 3
TLR4 NM_138554 NR_024168 NR_024169 toll-like receptor 4
TLR8 NM_138636 toll-like receptor 8
TLR9 NM_017442 toll-like receptor 9
TNF NM_000594 tumor necrosis factor
TNFRSF1B NM_001066 tumor necrosis factor receptor superfamily, member 1B
TNFSF10 NM_001190942 NM_001190943 NM_003810 NR_033994 tumor necrosis factor (ligand) superfamily, member 10
TOLLIP NM_019009 toll interacting protein
TRAF6 NM_004620 NM_145803 TNF receptor-associated factor 6
XCL1 NM_002995 chemokine (C motif) ligand 1
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
symbol refseq name
ABCB1 NM_000927 ATP-binding cassette, sub-family B (MDR/TAP), member 1
APAF1 NM_001160 NM_013229 NM_181861 NM_181868 NM_181869 apoptotic peptidase activating factor 1
ATM NM_000051 ataxia telangiectasia mutated
ATR NM_001184 ataxia telangiectasia and Rad3 related
BAI1 NM_001702 brain-specific angiogenesis inhibitor 1
BAX NM_004324 NM_138761 NM_138763 NM_138764 NR_027882 BCL2-associated X protein
BCL2 NM_000633 NM_000657 B-cell CLL/lymphoma 2
BID NM_001196 NM_197966 NM_197967 BH3 interacting domain death agonist
BIRC5 NM_001012270 NM_001012271 NM_001168 baculoviral IAP repeat-containing 5
BRCA1 NM_007294 NM_007297 NM_007298 NM_007299 NM_007300 NR_027676 breast cancer 1, early onset
BTG2 NM_006763 BTG family, member 2
CASP2 NM_032982 NM_032983 caspase 2, apoptosis-related cysteine peptidase
CASP3 NM_004346 NM_032991 caspase 3, apoptosis-related cysteine peptidase
CASP9 NM_001229 NM_032996 caspase 9, apoptosis-related cysteine peptidase
CCNB2 NM_004701 cyclin B2
CCNE2 NM_057749 cyclin E2
CDK1 NM_001170406 NM_001170407 NM_001786 NM_033379 cyclin-dependent kinase 1
CDK1 NM_001170406 NM_001170407 NM_001786 NM_033379 cyclin-dependent kinase 1
CDK4 NM_000075 cyclin-dependent kinase 4
CDKN1A NM_000389 NM_078467 cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A NM_000077 NM_058195 NM_058197 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
CHEK1 NM_001114121 NM_001114122 NM_001274 CHK1 checkpoint homolog (S. pombe)
CHEK2 NM_001005735 NM_007194 NM_145862 CHK2 checkpoint homolog (S. pombe)
CRADD NM_003805 CASP2 and RIPK1 domain containing adaptor with death domain
DNMT1 NM_001130823 NM_001379 DNA (cytosine-5-)-methyltransferase 1
E2F1 NM_005225 E2F transcription factor 1
E2F3 NM_001949 E2F transcription factor 3
EGR1 NM_001964 early growth response 1
EI24 NM_001007277 NM_004879 etoposide induced 2.4 mRNA
ESR1 NM_000125 NM_001122740 NM_001122741 NM_001122742 estrogen receptor 1
FADD NM_003824 Fas (TNFRSF6)-associated via death domain
FAS NM_000043 NM_152871 NM_152872 NR_028033 NR_028034 NR_028035 NR_028036 Fas (TNF receptor superfamily, member 6)
FASLG NM_000639 Fas ligand (TNF superfamily, member 6)
FOXO3 NM_001455 NM_201559 forkhead box O3
GADD45A NM_001924 growth arrest and DNA-damage-inducible, alpha
GML NM_002066 glycosylphosphatidylinositol anchored molecule like protein
HDAC1 NM_004964 histone deacetylase 1
HK2 NM_000189 hexokinase 2
IFNB1 NM_002176 interferon, beta 1, fibroblast
IGF1R NM_000875 insulin-like growth factor 1 receptor
IGFBP1 NM_000596 insulin-like growth factor binding protein 1
IL6 NM_000600 interleukin 6 (interferon, beta 2)
JUN NM_002228 jun proto-oncogene
KRAS NM_004985 NM_033360 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
LRDD NM_145886 NM_145887 leucine-rich repeats and death domain containing
MAPK8 NM_002750 NM_139046 NM_139047 NM_139049 mitogen-activated protein kinase 8
MDM2 NM_002392 Mdm2 p53 binding protein homolog (mouse)
MYC NM_002467 v-myc myelocytomatosis viral oncogene homolog (avian)
MYOD1 NM_002478 myogenic differentiation 1
NF1 NM_000267 NM_001042492 NM_001128147 neurofibromin 1
NFKB1 NM_001165412 NM_003998 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NQO1 NM_000903 NM_001025433 NM_001025434 NAD(P)H dehydrogenase, quinone 1
PCNA NM_002592 NM_182649 proliferating cell nuclear antigen
PLK3 NM_004073 polo-like kinase 3
PPM1D NM_003620 protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCA NM_002737 protein kinase C, alpha
PTEN NM_000314 phosphatase and tensin homolog
RB1 NM_000321 retinoblastoma 1
RELA NM_001145138 NM_021975 v-rel reticuloendotheliosis viral oncogene homolog A (avian)
RPRM NM_019845 reprimo, TP53 dependent G2 arrest mediator candidate
SERPINE1 NM_000602 NM_001165413 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 NM_014454 sestrin 1
SESN2 NM_031459 sestrin 2
SIAH1 NM_001006610 NM_003031 seven in absentia homolog 1 (Drosophila)
SIRT1 NM_001142498 NM_012238 sirtuin 1
STAT1 NM_007315 NM_139266 signal transducer and activator of transcription 1, 91kDa
TIMP3 NM_000362 TIMP metallopeptidase inhibitor 3
TNF NM_000594 tumor necrosis factor
TNFRSF10B NM_003842 NM_147187 NR_027140 tumor necrosis factor receptor superfamily, member 10b
TP53 NM_000546 NM_001126112 NM_001126113 NM_001126114 NM_001126115 NM_001126116 NM_001126117 tumor protein p53
TP53AIP1 NM_022112 tumor protein p53 regulated apoptosis inducing protein 1
TP73 NM_001126240 NM_001126241 NM_001126242 NM_005427 tumor protein p73
VCAN NM_001126336 NM_001164097 NM_001164098 NM_004385 versican
WT1 NM_000378 NM_024424 NM_024425 NM_024426 Wilms tumor 1
XRCC5 NM_021141 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
symbol refseq name
AES NM_001130 NM_198969 NM_198970 amino-terminal enhancer of split
APC NM_000038 NM_001127510 NM_001127511 adenomatous polyposis coli
AXIN1 NM_003502 NM_181050 axin 1
BCL9 NM_004326 B-cell CLL/lymphoma 9
BTRC NM_003939 NM_033637 beta-transducin repeat containing
CCND1 NM_053056 cyclin D1
CCND2 NM_001759 cyclin D2
CER1 NM_005454 cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
CHD8 NM_001170629 NM_020920 chromodomain helicase DNA binding protein 8
CREBBP NM_001079846 NM_004380 CREB binding protein
CSNK1A1 NM_001025105 NM_001892 casein kinase 1, alpha 1
CSNK2A1 NM_001895 NM_177559 NM_177560 casein kinase 2, alpha 1 polypeptide
CTBP1 NM_001012614 NM_001328 C-terminal binding protein 1
CTBP2 NM_001083914 NM_001329 NM_022802 C-terminal binding protein 2
CTNNB1 NM_001098209 NM_001098210 NM_001904 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 NM_001012329 NM_020248 catenin, beta interacting protein 1
CXXC4 NM_025212 CXXC finger protein 4
DKK1 NM_012242 dickkopf homolog 1 (Xenopus laevis)
DVL1 NM_004421 dishevelled, dsh homolog 1 (Drosophila)
DVL2 NM_004422 dishevelled, dsh homolog 2 (Drosophila)
EP300 NM_001429 E1A binding protein p300
FBXW2 NM_012164 F-box and WD repeat domain containing 2
FGF4 NM_002007 fibroblast growth factor 4
FOSL1 NM_005438 FOS-like antigen 1
FRAT1 NM_005479 frequently rearranged in advanced T-cell lymphomas
FZD1 NM_003505 frizzled homolog 1 (Drosophila)
FZD2 NM_001466 frizzled homolog 2 (Drosophila)
FZD3 NM_017412 frizzled homolog 3 (Drosophila)
FZD4 NM_012193 frizzled homolog 4 (Drosophila)
FZD5 NM_003468 frizzled homolog 5 (Drosophila)
FZD6 NM_001164615 NM_001164616 NM_003506 frizzled homolog 6 (Drosophila)
FZD7 NM_003507 frizzled homolog 7 (Drosophila)
FZD8 NM_031866 frizzled homolog 8 (Drosophila)
GSK3B NM_001146156 NM_002093 glycogen synthase kinase 3 beta
JUN NM_002228 jun proto-oncogene
KREMEN1 NM_001039570 NM_032045 kringle containing transmembrane protein 1
LEF1 NM_001130713 NM_001130714 NM_001166119 NM_016269 lymphoid enhancer-binding factor 1
LRP5 NM_002335 low density lipoprotein receptor-related protein 5
LRP6 NM_002336 low density lipoprotein receptor-related protein 6
MMP7 NM_002423 matrix metallopeptidase 7 (matrilysin, uterine)
MYC NM_002467 v-myc myelocytomatosis viral oncogene homolog (avian)
NKD1 NM_033119 naked cuticle homolog 1 (Drosophila)
NKD2 NM_033120 naked cuticle homolog 2 (Drosophila)
NLK NM_016231 nemo-like kinase
PITX2 NM_000325 NM_153426 NM_153427 paired-like homeodomain 2
PORCN NM_022825 NM_203473 NM_203474 NM_203475 porcupine homolog (Drosophila)
PPP2CA NM_002715 protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A NM_014225 NR_033500 protein phosphatase 2, regulatory subunit A, alpha
PYGO1 NM_015617 pygopus homolog 1 (Drosophila)
SENP2 NM_021627 SUMO1/sentrin/SMT3 specific peptidase 2
SFRP1 NM_003012 secreted frizzled-related protein 1
SFRP4 NM_003014 secreted frizzled-related protein 4
SMAD2 NM_001003652 NM_001135937 NM_005901 SMAD family member 2
SOX17 NM_022454 SRY (sex determining region Y)-box 17
TCF7 NM_001134851 NM_003202 NM_201632 NM_201634 NM_213648 NR_033449 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 NM_031283 transcription factor 7-like 1 (T-cell specific, HMG-box)
TLE1 NM_005077 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE2 NM_001144761 NM_001144762 NM_003260 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
WIF1 NM_007191 WNT inhibitory factor 1
WNT1 NM_005430 wingless-type MMTV integration site family, member 1
WNT10A NM_025216 wingless-type MMTV integration site family, member 10A
WNT11 NM_004626 wingless-type MMTV integration site family, member 11
WNT16 NM_016087 NM_057168 wingless-type MMTV integration site family, member 16
WNT2 NM_003391 NR_024047 wingless-type MMTV integration site family member 2
WNT2B NM_004185 NM_024494 wingless-type MMTV integration site family, member 2B
WNT3 NM_030753 wingless-type MMTV integration site family, member 3
WNT3A NM_033131 wingless-type MMTV integration site family, member 3A
WNT4 NM_030761 wingless-type MMTV integration site family, member 4
WNT5A NM_003392 wingless-type MMTV integration site family, member 5A
WNT5B NM_030775 NM_032642 wingless-type MMTV integration site family, member 5B
WNT6 NM_006522 wingless-type MMTV integration site family, member 6
WNT7A NM_004625 wingless-type MMTV integration site family, member 7A
WNT7B NM_058238 wingless-type MMTV integration site family, member 7B
WNT8A NM_058244 wingless-type MMTV integration site family, member 8A
WNT9A NM_003395 wingless-type MMTV integration site family, member 9A
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
symbol refseq name
AKT1 NM_001014431 NM_001014432 NM_005163 v-akt murine thymoma viral oncogene homolog 1
AKT2 NM_001626 v-akt murine thymoma viral oncogene homolog 2
AKT3 NM_005465 NM_181690 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
AURKA NM_003600 NM_198433 NM_198434 NM_198435 NM_198436 NM_198437 aurora kinase A
AURKB NM_004217 aurora kinase B
AURKC NM_001015878 NM_001015879 NM_003160 aurora kinase C
CASK NM_001126054 NM_001126055 NM_003688 calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CDC42BPA NM_003607 NM_014826 CDC42 binding protein kinase alpha (DMPK-like)
CDK1 NM_001170406 NM_001170407 NM_001786 NM_033379 cyclin-dependent kinase 1
CDK5 NM_001164410 NM_004935 cyclin-dependent kinase 5
CDK7 NM_001799 cyclin-dependent kinase 7
CDK9 NM_001261 cyclin-dependent kinase 9
CDKL1 NM_004196 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CHUK NM_001278 conserved helix-loop-helix ubiquitous kinase
CIT NM_007174 citron (rho-interacting, serine/threonine kinase 21)
EGFR NM_005228 NM_201282 NM_201283 NM_201284 epidermal growth factor receptor
ERBB3 NM_001005915 NM_001982 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
ERN1 NM_001433 endoplasmic reticulum to nucleus signaling 1
GSK3A NM_019884 glycogen synthase kinase 3 alpha
GSK3B NM_001146156 NM_002093 glycogen synthase kinase 3 beta
HCK NM_001172129 NM_001172130 NM_001172131 NM_001172132 NM_001172133 NM_002110 hemopoietic cell kinase
IKBKB NM_001190720 NM_001190721 NM_001190722 NM_001556 NR_033818 NR_033819 NR_033820 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE NM_001193321 NM_001193322 NM_014002 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INSR NM_000208 NM_001079817 insulin receptor
IRAK1 NM_001025242 NM_001025243 NM_001569 interleukin-1 receptor-associated kinase 1
IRAK2 NM_001570 interleukin-1 receptor-associated kinase 2
JAK1 NM_002227 Janus kinase 1
JAK2 NM_004972 Janus kinase 2
JAK3 NM_000215 Janus kinase 3
LIMK1 NM_002314 LIM domain kinase 1
LIMK2 NM_001031801 NM_005569 NM_016733 LIM domain kinase 2
MAP2K1 NM_002755 mitogen-activated protein kinase kinase 1
MAP2K2 NM_030662 mitogen-activated protein kinase kinase 2
MAP2K3 NM_002756 NM_145109 mitogen-activated protein kinase kinase 3
MAP2K6 NM_002758 mitogen-activated protein kinase kinase 6
MAP3K1 NM_005921 mitogen-activated protein kinase kinase kinase 1
MAP3K11 NM_002419 mitogen-activated protein kinase kinase kinase 11
MAPK1 NM_002745 NM_138957 mitogen-activated protein kinase 1
MAPK11 NM_002751 mitogen-activated protein kinase 11
MAPK12 NM_002969 mitogen-activated protein kinase 12
MAPK13 NM_002754 mitogen-activated protein kinase 13
MAPK14 NM_001315 NM_139012 NM_139013 NM_139014 mitogen-activated protein kinase 14
MAPK3 NM_001040056 NM_001109891 NM_002746 mitogen-activated protein kinase 3
MAPK9 NM_001135044 NM_002752 NM_139068 NM_139069 NM_139070 mitogen-activated protein kinase 9
MAPKAPK2 NM_004759 NM_032960 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK3 NM_004635 mitogen-activated protein kinase-activated protein kinase 3
MARK2 NM_001039469 NM_001163296 NM_001163297 NM_004954 NM_017490 MAP/microtubule affinity-regulating kinase 2
MTOR NM_004958 mechanistic target of rapamycin (serine/threonine kinase)
MYLK NM_053025 NM_053026 NM_053027 NM_053028 NM_053031 NM_053032 myosin light chain kinase
MYLK2 NM_033118 myosin light chain kinase 2
PAK1 NM_001128620 NM_002576 p21 protein (Cdc42/Rac)-activated kinase 1
PAK4 NM_001014831 NM_001014832 NM_001014834 NM_001014835 NM_005884 p21 protein (Cdc42/Rac)-activated kinase 4
PDGFRB NM_002609 platelet-derived growth factor receptor, beta polypeptide
PDK1 NM_002610 pyruvate dehydrogenase kinase, isozyme 1
PDK2 NM_002611 XR_109402 pyruvate dehydrogenase kinase, isozyme 2
PDPK1 NM_002613 NM_031268 3-phosphoinositide dependent protein kinase-1
PLK1 NM_005030 polo-like kinase 1
PLK2 NM_006622 polo-like kinase 2
PLK3 NM_004073 polo-like kinase 3
PLK4 NM_001190799 NM_001190801 NM_014264 polo-like kinase 4
PRKCA NM_002737 protein kinase C, alpha
PRKCB NM_002738 NM_212535 protein kinase C, beta
PRKCD NM_006254 NM_212539 protein kinase C, delta
PRKCE NM_005400 protein kinase C, epsilon
PRKCG NM_002739 protein kinase C, gamma
PRKCI NM_002740 protein kinase C, iota
PRKCQ NM_006257 protein kinase C, theta
PRKCZ NM_001033581 NM_001033582 NM_002744 protein kinase C, zeta
PTK2B NM_004103 NM_173174 NM_173175 NM_173176 PTK2B protein tyrosine kinase 2 beta
RAF1 NM_002880 v-raf-1 murine leukemia viral oncogene homolog 1
RIPK1 NM_003804 receptor (TNFRSF)-interacting serine-threonine kinase 1
ROCK1 NM_005406 Rho-associated, coiled-coil containing protein kinase 1
RPS6KB1 NM_003161 ribosomal protein S6 kinase, 70kDa, polypeptide 1
TBK1 NM_013254 TANK-binding kinase 1
TYK2 NM_003331 tyrosine kinase 2
TFRC NM_001128148 NM_003234 transferrin receptor (p90, CD71)
PGK1 NM_000291 phosphoglycerate kinase 1
TBP NM_001172085 NM_003194 TATA box binding protein
GUSB NM_000181 glucuronidase, beta
HPRT1 NM_000194 hypoxanthine phosphoribosyltransferase 1
   
[ List of optimised nucleic acid tests ]