Choosing the Right Cell-Based Assay for Your Research Goals
Drug discovery pipelines now produce thousands of candidate molecules in a short amount of time, but moving early in vitro results into clinically meaningful results is still hard. Too many late-stage failures occur due to early screening models that don’t reflect real disease biology. This has driven new demand for biologically relevant cell-based assays that underlie mechanism-driven and predictive […]
Applications of Precision-Cut Lung Slices (PCLS) in Airway Disease Research
The drug discovery pipeline for respiratory conditions is notorious for its steep drop-off rate. Millions of pounds evaporate globally when promising leads hit a brick wall during clinical trials. Why? Because traditional pre-clinical models frequently flatter to deceive. Monolayer cell cultures do not provide architectural depth, while animal models do not recapitulate human immunology perfectly.q Meanwhile, on the grounds of bridging this […]