Bioassay Scientist II/III (Immuno-Oncology)
Cellomatics Biosciences Ltd. is one of the UK’s fastest growing Contract Research Organisations (CRO) providing specialist pre-clinical laboratory services to support the drug development programmes of biotech and pharmaceutical companies.
Cellomatics Biosciences Ltd has an exciting opportunity for a highly motivated Bioassay Scientist II/III (Immuno-Oncology) to join our operations in Nottingham, UK. The successful candidate will join a dynamic, collaborative team and report to the Bioassay Study Manager.
The ideal candidate will have a strong background in immunology and immuno-oncology, with demonstrated expertise in developing and applying complex in vitro immuno-oncology assays to support therapeutic evaluation. This includes hands-on experience in immune cell functional assays, co-culture systems, and mechanism-of-action studies for biologics and advanced therapeutics.
You will work in a matrixed environment to design, execute, and interpret sophisticated bioassays that inform drug discovery and early clinical development strategies.
Job Responsibilities:
- Design, develop, and optimise in vitro immuno-oncology assay platforms, including co-culture and functional immune assays
- Execute and analyse assays assessing immune cell activation, cytotoxicity, proliferation, cytokine release, and immune modulation
- Support evaluation of therapeutic modalities including antibodies, ADCs, and immune modulators
- Perform laboratory work and prepare SOPs and COSHH documentation
- Analyse, interpret, and communicate complex scientific data to internal teams and clients
- Present findings to internal and external stakeholders
- Lead method development, validation, transfer, and optimisation
- Troubleshoot experimental challenges and ensure high-quality, timely project delivery
- Prepare detailed scientific reports aligned with client requirements
- Maintain inventory of reagents and consumables
- Drive continuous improvement in assay robustness, quality, and innovation
- Support accreditation processes and client audits
- Contribute to business development activities and client interactions
- Develop training materials and mentor team members
- Support implementation of new technologies and platforms
Qualifications and Essential Skills:
- PhD in Immunology, Immuno-Oncology, or a related discipline, or MSc with at least 3 years of relevant industry/CRO experience
- Strong hands-on experience in:
-Primary human immune cell isolation and culture (e.g. PBMCs, T cells, NK cells)
-Immune cell functional assays (cytotoxicity, activation, proliferation, cytokine profiling)
-Co-culture systems (tumour–immune interactions)
-Flow cytometry and multiparametric analysis
-ADC and biologics testing (mechanism-of-action studies preferred)
-2D and 3D in vitro models
-Biochemical and molecular assays
-High-throughput screening platforms
- Proven experience working with human immune cells
- Demonstrated track record in assay development and translational model deployment
- Excellent communication and data presentation skills
- Strong analytical and problem-solving abilities
- Ability to work independently and collaboratively in a fast-paced environment
- Proactive, adaptable, and results-driven mindset
- Strong organisational and multitasking skills
- Proficiency in MS Office (Excel, Word, Outlook)
Location: 10 Colwick Quays Business Park, Road No 2, Colwick, NG4 2JY, Nottingham
Job Type: Full-time (37.5hrs per week)
Salary: Up to £36,000 per annum, depending on experience and skill set
Contract: Permanent
What we offer:
Our benefits package includes a competitive salary, discretionary performance related bonus annually, an initial 3% employer pension contribution, 24 days annual leave. This position is based at our facility at 10 Colwick Quays Business Park, Nottingham, UK.
To apply, please confirm your status of eligibility to work in the UK and send your CV with a covering letter outlining why you feel you would be suitable for this role to info@cellomaticsbio.com.
