Precision Cut Lung Slices & Fibrosis Model
Respiratory Assays
Precision Cut Lung Slices & Fibrosis Model
Cytokine release after fibrotic stimulation and an anti-fibrotic compound
Healthy-donor PCLS show cytokine release after fibrotic stimulation and Nintedanib.
PCLS from two healthy donors treated with fibrotic cocktail ± Nintedanib; supernatant cytokine panel measured by Luminex Assay (n=2; n=1 for Nintedanib). (Stats: one-way ANOVA; n as stated; mean ± SEM; *p<0.05, **p<0.01, ***p<0.001
Cytokine release
Nintedanib modulates cytokine release in fibrotic-donor PCLS under fibrotic stimulation.
Fibrotic-donor PCLS were treated with Nintedanib ± fibrotic cocktail (48 h), and supernatant inflammatory markers were measured by Luminex Assay; n=1 (Stats: one-way ANOVA; n as stated; mean ± SEM; *p<0.05, **p<0.01, ***p<0.001)
Gene expression
Nintedanib alters fibrotic gene expression in fibrotic-donor PCLS.
PCLS (fibrotic donor) were treated with Nintedanib ± fibrotic cocktail and gene expression analysed (n=1) (Stats: one-way ANOVA; n as stated; mean ± SEM; *p<0.05, **p<0.01, ***p<0.001).
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