ADCP: Antibody Dependent Cellular Phagocytosis

ADCP is a mechanism by which macrophages engulf and eliminate the tumour cells targeted with monoclonal antibodies.

The target Raji cells were pre-treated with or without Rituximab at different concentrations and stained with pHrodo Red Cell Labelling (red). The THP-1 derived macrophages were stained with calcein staining (green). To assess antibody-dependent cellular phagocytosis of target Raji cells by THP-1 derived macrophages the two cell types were co-cultured for 6 hours. Data is represented as the red fluorescence intensity (RFI)  at 0 hours vs. 6 hours in all treatment groups.

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