It is a potential mechanism for a cell to avoid malignant transformation. However, senescence can also promote cancer development by altering the cellular microenvironment through a senescence-associated secretory phenotype (SASP). At least, three types of cellular stress such as activation of oncogenes, loss of tumor suppressor genes, and chemo/radiotherapy can induce cell senescence (Zeng et al., 2018).

Cellomatics can assist with a wide variety of senescence assays to suit your project.

Senescence Assay

Primary human chondrocytes treated with H2O2 for 24 hours followed by a 72 hours recovery period and then treated with ABT 263 (a known senolytic). Cells were fixed followed by immunofluorescence staining for DAPI and β-galactosidase.

Request a consultation with Cellomatics Biosciences today

Our experienced team of in vitro laboratory scientists will work with you to understand your project and provide a bespoke project plan with a professional, flexible service and a fast turnaround time.

To request a consultation where we can discuss your exact requirements, please contact Cellomatics Biosciences.