Poly (ADP-ribose) polymerases (PARPs) are a family of enzymes present in all somatic cells that help damaged cells repair themselves. PARPs are also involved in the transcriptional regulation of several signalling pathways, including genes involved in inflammation. PARPs, and particularly the tankyrases have become important cancer drug targets. At Cellomatics, we offer PARP assays to support a range of projects.
Scientific evidence suggests that PARP is overexpressed in lung, ovarian, and breast cancer, and PARP inhibitors are showing dramatic therapeutic potential for breast and ovarian cancer treatments.
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Dose Response for Talazoparib and Minocycline of PARP activity and Proliferation in UWB1.289
The ovarian cancer cell line UWB1.289 was treated for 24 hours with increasing concentrations of Talazoparib and Minocycline. PARP activity was measured by an in vitro cell free enzymatic assay. Proliferation was assessed by BrdU incorporation (n=3±SEM).
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