B Lymphocyte Based Assays
In addition to their role in humoral immunity, it is now established that B lymphocytes contribute directly to cellular immunity via at least three mechanisms: (1) they serve as antigen-presenting cells (APCs) that enhance T lymphocyte–mediated immunity; (2) they function as bona fide cellular effectors that produce inflammatory cytokines; and (3) modulate immune responses.
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Pan-B lymphocyte IgE release assay
Pan B lymphocytes were freshly isolated from the peripheral blood of a healthy volunteer. Cells were stimulated with IL4+IL13 for 48 hours in the presence or absence of Dexamethasone. Increased IgE release was observed following IL4+IL13 stimulation; this was inhibited by pre-treatment with Dexamethasone (mean ± SEM).
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