COPD
Respiratory Assays
COPD
The GOLD initiative defines COPD as “a disease state characterized by airflow limitation that is not fully reversible. The airflow limitation is usually both progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases.” The American Thoracic Society defines COPD in terms of chronic bronchitis and emphysema. Chronic bronchitis is characterized by the clinical symptoms of excessive cough and sputum production; emphysema refers to chronic dyspnea, resulting from enlarged air spaces and destruction of lung tissue. COPD is the fourth leading cause of death worldwide.
Our COPD research services support the investigation of disease mechanisms and the evaluation of novel therapeutic approaches for chronic obstructive pulmonary disease.
Treatments and Timepoints
COPD – Air Liquid Interface (ALI) model
TEER
TEER dynamics and LDH release during differentiation.
Cells were treated from day 2 with stimulants (media changed and fresh stimulants added every other day for 21 days. TEER was measured across the timepoints and normalised to Day 2 (n=3±SEM)
Mucin expression in COPD ALI model by histology
IL-13 increases epithelial mucin (MUC5AC/MUC5B) staining.
Immunohistochemistry in unstimulated vs IL-13 stimulated samples; MUC5AC and MUC5B staining scored as positive (brown) cells.
These COPD research services provide researchers with access to clinically relevant in vitro models and robust assay platforms for respiratory drug discovery.
Request a consultation with Cellomatics Biosciences today
Cellomatics offers customised COPD research services to help biotechnology and pharmaceutical companies accelerate the development of innovative respiratory therapies. Our experienced team of in vitro laboratory scientists will work with you to understand your project and provide a bespoke project plan with a professional, flexible service and a fast turnaround time.
To request a consultation where we can discuss your exact requirements, please contact Cellomatics Biosciences.
