A compendium of molecular capabilities
Introduction Understanding the intricate organisation and interaction of organisms, organelles, tissues, cells, and biomolecules, and how their dysregulation results in disease, is vital for the effective development of potential therapeutics and experimental platforms. The central dogma of molecular biology provides the fundamental building blocks of almost all eukaryotic functional pathways, through the relationship of DNA […]
NASH (Non-alcoholic Steatohepatitis)
In our latest blog we discuss Non-alcoholic Steatohepatitis (NASH), how it is caused and how Cellomatics Biosciences is at the forefront of designing and validating in vitro models that replicate specific pathological features of NASH to support our clients’ drug development efforts. Chronic liver disease is a significant cause of mortality, morbidity, and healthcare resource […]
INNOBEX™: in vitro blood–brain barrier model developed at Cellomatics
Over the years, several companies have designed different models to represent the blood-brain barrier (BBB) in vitro. These range from simple one cell type models to complex organ on a chip or microfluidic structures. However, there are several drawbacks associated with these models, with single cell models not receiving feedback from the other cells surrounding […]
Posing (Neuro)inflammatory questions about dementia
To mark Parkinson’s Awareness Month our Senior Bioassay Scientist Dr Gareth Edwards delves into the role of neuroinflammation and its contribution to the global increase in dementia and associated neurodegenerative neuropathies. Inflammation plays a vital role in the response to many diseases: exposure to stimuli initiates a signalling cascade which amplifies downstream responses, leading to […]
Science Communication: Immune Cell Chemotaxis
In our first instalment of Science Communication our senior bioassay scientist delves into immune cell chemotaxis and the capabilities we have for this research at Cellomatics. In the intricate theatre of the human immune system, a meticulously orchestrated performance unfolds, choreographed by a specialised ensemble of immune cells. These extraordinary cellular entities exhibit a unique […]