3D Cell Culture vs. 2D Cell Culture: What Researchers Need to Know
Cellular culturing continues to be an important technique for validating targets, developing models of diseases, and conducting preclinical tests of drugs. For many years, 2D cell cultures were considered the most convenient and efficient method to explore cellular pathways, test compounds, and gather experimental information. However, many people have met with a recurring issue when […]
How In Vitro Skin Models are Improving Dermatology Drug Discovery
The pharmaceutical industry loves a shiny new panacea. Walk into any modern drug discovery symposium, and you will overhear seemingly constant discussion of how next-gen lab platforms are making traditional preclinical methods exotic relics. In the dermatology sector, the current darling of the benchtop is the in vitro human skin model. Proponents claim these sophisticated […]
Challenges in Preclinical Rheumatoid Arthritis Research – and Emerging Solutions
Let’s face it: the translation of a pipeline from benchside triumph to bedside reality is often where pharmaceutical dreams go to die. Pharma has spent billions trying to find therapeutics for autoimmune diseases for the last several decades, only to crash on the rocks when the clinical trials were conducted. This harsh truth is more […]
Why 3D Spheroid Invasion Assays Are Transforming Oncology Research
Cancer research is evolving rapidly, driven by advances in targeted therapies, immunotherapies, and precision medicine. As treatment strategies become more sophisticated, the need for predictive preclinical models has never been greater. While traditional two-dimensional (2D) cell cultures have long been a cornerstone of oncology research, they often fail to accurately replicate the complexity of human […]
Beyond Off-the-Shelf Solutions: When Does Drug Discovery Need Custom Assays?
In the competitive world of drug discovery, generating reliable and actionable data is essential for making informed decisions and advancing promising therapies. Commercial assay kits have become a popular choice because they are convenient, readily available, and easy to implement. For many routine applications, these standardized solutions work well. However, as research grows more complex, […]
Choosing the Right Cell-Based Assay for Your Research Goals
Drug discovery pipelines now produce thousands of candidate molecules in a short amount of time, but moving early in vitro results into clinically meaningful results is still hard. Too many late-stage failures occur due to early screening models that don’t reflect real disease biology. This has driven new demand for biologically relevant cell-based assays that underlie mechanism-driven and predictive […]
Contract Research Organisation selection – important considerations
In this blog, Cellomatics CEO and Founder Shailendra Singh provides his insights into the important considerations which must be made when identifying and building partnerships with Contract Research Organisations (CROs). Framing the CRO’s role in early discovery In early discovery, the primary role of a CRO is to reduce scientific uncertainty, whereas in later stages […]
Applications of Precision-Cut Lung Slices (PCLS) in Airway Disease Research
The drug discovery pipeline for respiratory conditions is notorious for its steep drop-off rate. Millions of pounds evaporate globally when promising leads hit a brick wall during clinical trials. Why? Because traditional pre-clinical models frequently flatter to deceive. Monolayer cell cultures do not provide architectural depth, while animal models do not recapitulate human immunology perfectly.q Meanwhile, on the grounds of bridging this […]
Case study: High-throughput functional screening in human translational models for early drug discovery
This case study demonstrates Cellomatics’ capability to integrate: High-throughput screening (HTS) Complex primary human cell models Multiparametric functional readouts Cross-validation of hits in disease-relevant systems Scientific objective To systematically evaluate the functional impact of 100 siRNA-mediated gene knockdowns in primary human keratinocytes derived from both healthy and psoriatic donors, across multiple disease-relevant biological pathways and […]
Meet the team: Arun Flynn
As a child, Arun’s mum always thought he would grow up to become an inventor because he was always trying to understand how the things around him worked and then how he could fix them. This fascination then transformed into a focus towards the human body, how it works and how diseases are formed and […]