Immune cell chemotaxis
Immunology Models
Immune Cell Chemotaxis Assay
Cellomatics offers a range of established Chemotaxis assays in both primary immune cells and immortalised cell lines. Utilising transwell systems and chemoattractant, cell migration between the apical and basal chambers is quantified in the presence or absence of test therapeutics. Agonist and antagonist concentration response curves can be applied to obtain the EC50 of test therapeutics against a range of different chemoattractant.
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Available formats
Standard 96-well format.
Alternative format offerings available upon request.
Pilot assay development is available as a standalone service, or as a built in checkpoint for full studies
FAQ's
This assay measures the directed migration of immune cells in response to chemoattractant gradients, providing insight into immune cell trafficking and inflammatory responses.
Cellomatics employs transwell systems and real-time imaging platforms to quantify migration parameters such as speed, directionality, and persistence.
Yes. Primary immune cells derived from PBMCs are routinely used to ensure physiological relevance and improve translational value. This is further supported at Cellomatics through in-house blood collection and fresh immune cell isolation, ensuring high cell viability, consistency, and more predictive biological responses.
By assessing how compounds modulate immune cell migration, researchers can evaluate therapeutic potential in diseases involving inflammation, autoimmunity, or cancer metastasis.
Yes. Assay conditions, including chemoattractants, cell types, and incubation parameters, can be tailored to specific research objectives. At Cellomatics, this flexibility is supported through the use of primary human immune cells, in-house isolation capabilities, and optimised assay design, enabling precise modelling of immune cell migration in disease-relevant contexts.